1 SYK is a candidate kinase target for the treatment of advanced prostate cancer
نویسندگان
چکیده
Division of Toxicology, Leiden Academic Center for Drug Research and Department of Molecular Cell Biology, Institute of Biology, Leiden University, Leiden, the Netherlands; Department of Urology, Leiden University Medical Center, Leiden, The Netherlands; Galapagos BV, Leiden, The Netherlands; Department of Urology and Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands
منابع مشابه
SYK is a candidate kinase target for the treatment of advanced prostate cancer.
Improved targeted therapies are needed to combat metastatic prostate cancer. Here, we report the identification of the spleen kinase SYK as a mediator of metastatic dissemination in zebrafish and mouse xenograft models of human prostate cancer. Although SYK has not been implicated previously in this disease, we found that its expression is upregulated in human prostate cancers and associated wi...
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تاریخ انتشار 2014